Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2025-03-10 Cooperative journals: 《中国全科医学》
Abstract： Background Erectile dysfunction（ED）has a high incidence and causes significant harm. The Miao medicine Zhuzhi medicinal moxibustion therapy belongs to the traditional "moxibustion with medication interposed". It is commonly used in clinical practice for the treatment of ED. But it lacks clinical evidence. Objective To explore the clinical efficacy of the Miao medicine Zhuzhi medicinal moxibustion therapy in the treatment of erectile dysfunction（ED）. Methods Sixty patients with ED from the outpatient department of the Acupuncture and Department of moxibustion and the urology，first affiliated hospital of Guizhou university of traditional Chinese medicine from December 2021 to March 2024 were selected as the research objects. They were randomly divided into the Sildenafil group and the Miao medicine Zhuzhi medicinal moxibustion group. Each group had 30 cases. In the Sildenafil group，50 mg of sildenafil citrate tablets were taken orally 1 hour before sexual activity. In the Miao medicine Zhuzhi medicinal moxibustion group，the indirect moxibustion method was adopted. The acupoints selected were CV 6（Qi Hai），CV 4（Guan Yuan），CV 3（Zhong Ji），KI 12（Da He），and CV 2（Qu Gu）；BL 23 （Shen Shu），BL 32（Ci Liao），BL 30（Bai Huan Shu），BL 34（Xia Liao），and BL 54（Zhi Bian）. The two groups of acupoints were used alternately. The treatment was done once every other day. Each treatment lasted for 40 minutes. Both groups were treated for 30 days. After treatment，the efficacy of the two groups was evaluated. The changes in serum testosterone（T） levels before and after treatment in both groups were compared. The scores of the International Index of Erectile Function（IIEF），Self-Rating Anxiety Scale（SAS），Self-Rating Depression Scale（SDS），and TCM clinical syndrome scores before and after treatment and during the follow-up period（2 weeks after treatment）were also compared between the two groups.Results The total effective rate in the Miao medicine Zhuzhi medicinal moxibustion group was 85.71%（24/28）. The total effective rate in the Sildenafil group was 86.67%（26/30）. There was no statistically significant difference between the two groups（χ2 =3.291，P=0.385）. Intra-group comparison：there was no statistically significant difference in T before and after treatment in the Miao medicine Zhuzhi medicinal moxibustion group（P>0.05），while T increased after treatment in the Sildenafil group compared to before treatment（P<0.05）. The IIEF scores in both groups increased after treatment and during the follow-up period compared with those before treatment（P<0.05）. There was no statistically significant difference in the IIEF scores during the follow-up period compared with those after treatment in the Miao medicine Zhuzhi medicinal moxibustion group（P>0.05）. The IIEF scores during the follow-up period in the Sildenafil group were lower than those after treatment（P<0.05）. The SAS，SDS，and TCM syndrome scores in the Miao medicine Zhuzhi medicinal moxibustion group decreased after treatment and during the follow#2;up period compared with those before treatment（P<0.05）. There was no statistically significant difference in the SAS，SDS，and TCM syndrome scores before and after treatment and during the follow-up period in the Sildenafil group（P>0.05）. The SAS，SDS，and TCM syndrome scores in the Miao medicine Zhuzhi medicinal moxibustion group during the follow-up period were lower than those after treatment（P<0.05）. Inter-group comparison：After treatment，the T value and IIEF scores in the Sildenafil group were higher than those in the Miao medicine Zhuzhi medicinal moxibustion group（P<0.05）. After treatment，the SAS，SDS，and TCM syndrome scores in the Miao medicine Zhuzhi medicinal moxibustion group were lower than those in the Sildenafil group（P<0.05）. During the follow-up period，the SAS，SDS，and TCM syndrome scores in the Miao medicine Zhuzhi medicinal moxibustion group were lower than those in the Sildenafil group（P<0.05）. There was no statistically significant difference in the IIEF scores between the two groups of subjects during the follow-up period（P>0.05）. During the treatment process，2 cases in the Sildenafil group experienced symptoms such as dry mouth，headache，and facial flushing. These symptoms could be relieved by rest. No serious adverse events occurred in either the Sildenafil group or the Miao medicine Zhuzhi medicinal moxibustion group. Conclusion The efficacy of the Miao medicine Zhuzhi medicinal moxibustion therapy is equivalent to that of sildenafil in the treatment of ED. The Miao medicine Zhuzhi medicinal moxibustion therapy has more advantages than sildenafil in improving the short-term and long-term anxiety and depression symptoms and TCM syndrome scores of patients with ED. Sildenafil is superior to the Miao medicine Zhuzhi medicinal moxibustion therapy in improving the T value and short-term erectile function of patients with ED.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-09-11
Abstract： Background Vedolizumab（VDZ） and Ustekinumab（UST） are both effective treatments for Crohn's disease（CD）. However， there are fewer comparative studies of these biologics in biologic-naïve patients with CD.Objective To compare the efficacy and safety of real-world UST and VDZ in biologic-naïve patients with moderately to severely active CD and to identify predictive factors associated with clinical efficacy. Methods Patients treated with VDZ or UST as the primary biologic agent for moderately to severely active CD were included from the First Affiliated Hospital of Zhejiang Chinese Medicine University from January 2021 to January 2023. Clinical efficacy at Weeks 14 and 52， endoscopic efficacy， and treatment persistence at Week 52 were evaluated in a retrospective cohort. Factors influencing clinical remission at Week 52 were analyzed， and adverse drug reactions during treatment were documented. Results A total of 72 patients with CD were included，with 27 receiving VDZ and 45 receiving UST. Of these， 67 completed 14 weeks of treatment （24 VDZ and 43 UST），and 57 completed 52 weeks of treatment （18 VDZ and 39 UST）. There were no statistically significant differences in clinical response rates or clinical remission rates at 14 weeks between UST and VDZ（P>0.05）. Similarly， at 52 weeks，no statistically significant differences were observed in clinical response rates or clinical remission rates between UST and VDZ（P>0.05）. Endoscopic response rates and endoscopic remission rates at 52 weeks also showed no significant differences between the treatments（P>0.05）. UST［86.7%（39/45）］ had a higher 52-week treatment persistence compared to VDZ［66.7%（18/27）］（P=0.043）. Multifactorial Logistic regression analysis indicated that age（OR=0.965，95%CI=0.938-0.993）and clinical response at Week 14（OR=8.483，95%CI=1.699-42.352）were significant factors for clinical remission at Week 52 in UST-treated patients. No multifactorial analysis was conducted for VDZ as no factors influencing clinical remission at Week 52 were identified in the univariate analysis. Adverse event rates were 7.4%（2/27） for VDZ and 4.4%（2/45） for UST，with no statistically significant difference between the groups（P>0.05）. Conclusion The clinical and endoscopic efficacy of UST in biologic-naïve patients with moderately to severely active CD is comparable to VDZ. However， the 52-week treatment persistence rate is higher for UST. Age and clinical response at Week 14 correlate with clinical remission at Week 52 in UST treated CD patients. Safety profiles were similar between the two groups.
Peer Review Status:
Awaiting Review
submitted time 2024-05-22 Cooperative journals: 《中国全科医学》
Abstract： Background Knee injuries are common military training injuries，which seriously affect the train， combat effectiveness. Ultrasound therapy and Qingpeng ointment are commonly used to treat sports training injuries. However， the protective effectiveness of Ultrasound combined with the external use of Qingpeng ointment for Knee injury in sports training injury patients is less reported. Objective To comprehensively assess the clinical efficacy of Qingpeng ointment combined with ultrasound therapy in the treatment of knee injuries caused by military training. Methods Fifty-six patients with knee injuries were selected from 2022-05 to 2022-07 in the Fifth Pentry Outpatient Clinic，the General Hospital of Western Theater Command PLA，and randomly divided into a control group and an intervention group. The control group received ultrasound therapy with an ordinary coupling agent，and the intervention group received ultrasound therapy combined with Qingpeng ointment. The Lysholm knee joint score，VAS score，Hamilton Depression Scale-17（HAMD-17），and knee range of motion were compared between the two groups after a twenty-minute intervention. Results Two groups had no significant differences in demographics（P>0.05）. Compared with the control group，the knee passive range of motion in the intervention group was significantly greater（P<0.05）. The HAMD-17 score decreased in the intervention group，while there was no change in the control group. The Lysholm knee joint score and VAS score were no significant differences between the two groups（P<0.05）. Conclusion Qingpeng ointment combined with ultrasound therapy and ultrasound therapy with ordinary coupling agents can significantly improve knee joint function，reduce pain in patients with knee injuries. As a special coupling agent for ultrasound therapy，Qingpeng ointment has certain advantages over ordinary coupling agents.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-10-08 Cooperative journals: 《知识管理论坛》
Abstract： [Purpose/significance] The purpose of this paper is to promote the science museum to play its role of social education and publicity through the sustainable development research of intelligent interactive exhibition, and to provide important reference for the library to enhance its comprehensive service function. [Method/process] This paper combed the function definition and effects of intelligent interactive exhibition, compared it with other education forms and summarized the ways of interaction. Then, we expounded the current development situation of Chinese and foreign intelligent interactive exhibition, and made a comparative analysis of the development process, theoretical research, functional effect and innovative concept of intelligent interactive exhibition in Chinese and foreign science and technology museums, and found out the existing problems in the development of intelligent interactive exhibition in China. [Results/conclusions] After exploring the deep-seated reasons behind the low popularity of intelligent interactive exhibitions in Science Museums, it is recommended that the manager of science and technology museum should consider the complete scene that audiences visit science and technology museum; informal education of science and technology museum must be closely integrate with the formal education, to realize linkage resource sharing; By optimizing the current mode of intelligent interactive exhibition, the enthusiasm of UGC will be encouraged to the greatest extent, and the originality and universality of high-quality intelligent interactive exhibition will be gradually enhanced, so as to promote the popularization of scientific knowledge and the improvement of public scientific literacy.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-08-27 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] Along with the increasing advance of the modern digital technology, digital reading has become the main reading mode. Through comparison and analysis of digital reading and paper reading, this paper clarifies the relationship between digital reading and paper reading, and provides reference for optimizing the digital resource construction and reading promotion service in our country.[Method/process] This paper reviews the literature on digital reading and paper reading in foreign countries, and finds that there are three clusters resulting from comparative study. They are reading preference, reading comprehension and reading experience. Therefore, the paper is analyzed in detail from these three aspects.[Result/conclusion] The foreign literatures mainly use the methods of experiment, questionnaire survey, depth interview, eye-tracking measures and electroencephalogram (EEG) to study the characteristics and differences of digital reading and paper reading. Digital reading and paper reading in different aspects present their own unique advantages and regularities. In the digital age, the two parties should complement each other. This paper puts forward the enlightenment to China's related research and library reading promotion service.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-08-26 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] Internet public information communication is a systematic, dynamic and complex life cycle. The study of the dynamic mechanism of public information dissemination in the Internet will help to better understand its complexity and systematicness. [Method/process] The research sets out to construct the complete framework of the dynamic mechanism of Internet public opinion information communication, on the basis of literature review on the dynamic mechanism of Internet public opinion according to the two dimensions of internal power and external power, and makes a comparative analysis the specific influencing factors. [Result/conclusion] Existing research focus on the three internal factors such as participation subject, event information, carrier platform and external environment as external factors. On this basis, this study analyzes the interactive game between the elements of Internet public opinion, sums up the process of modeling the dynamic mechanism of Internet public information communication. Future research will move towards small worlds, large data, and cloud communication.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-07-26 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] As the WeChat public platform promotes the intelligent level of library information dissemination and enhances the efficiency of library services, it has been widely used by Chinese libraries as an important self-media platform. In this context, this paper attempts to compare the WeChat public platform of university libraries and public libraries by the data of WeChat public platform.[Method/process]Firstly, the external and internal description data pushed in WeChat public platform was collected via the big data platform of social media and web crawler technology. After cleaning, this data was stored in the Mongo DB database. Secondly, the WeChat communication Index (WCI) was calculated through corresponding algorithm. At the time, the latent dirichlet allocation (LDA) was applied to carry out the topic classification research of texts. Finally, the conceptand quantitative method of information accepting and adopting index(IA&AI) was proposed, and the text feature was extracted by setting of IA&AI threshold.[Result/conclusion] There is strongly positive correlation between the number of readings and the number of praises; theoverall influence of the public platform of university libraries is slightly lower than that of public libraries, but the polarization of WCI exists in both kinds of libraries; after comparative analysis, the similarities and differences of topic classification and text features in high(or low) IA&AI's text are found.Finally, based on the research conclusions, some suggestions were put forward to operate the WeChat public platform of the two kinds of libraries.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-07-26 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] The paper compared and analyzed the undergraduate and master education in Chinese and American universities to provide reference for future medical informatics education in China.[Method/process] Taking the opening time and college level as the selection criteria, 10 representative universities from China and the United States were selected as the research objects. Through online research, the paper comprehensively analyzed the general situation of medical informatics education in China and the United States from the aspects of basic requirements, curriculum, teacher strength, teaching methods and employment prospects.[Result/conclusion] Although China has made some achievements in medical informatics education after decades of exploration and practice, compared with the United States, China still has some shortcomings. In terms of basic requirements for admission, China mainly concentrates on the undergraduate education so that the high-level personnel training system is imperfect; in terms of curriculum, the content of courses is monotonous and the proportion of non-medical basic courses is too high, and the interdisciplinary integration is not obvious; in terms of teachers' strength, the teacher's subject background is single and the distribution of teachers' professional titles is unbalanced; in terms of education and teaching methods, the teaching methods are simple and there are fewer practical opportunities for students; in terms of employment prospects, students knowledge system is not systematic and the employment prospects are limited. Therefore, China should conform to the development requirements of the big data science research paradigm, speed up the cultivation of high-level medical informatics; improve the curriculum and content settings, broaden the scope of subject knowledge system; optimize the allocation of teachers to attract multi-disciplinary background talents; enrich training methods, and pay attention to the combination of theory and practice.
Subjects: Library Science，Information Science >> Information Processing Subjects: Library Science，Information Science >> Utilization of Information submitted time 2023-05-06
Abstract： In order to utilize the data source of papers and patents for joint analysis, to evaluate the scientific achievements from multiple perspectives, to track the research frontiers and to study the mutual relationship between science and technology, this paper sorted out the concepts and methods commonly used in the bibliometrics and patentometrics, thoroughly compared and analyzed their similarities and differences, provided a reasonable explanation for these differences and summarized the basic methods and key points for paper-patent joint analysis. The research shows that the bibliometrics emphasize the influence of academic achievements whereas the patentometrics emphasize the evolvement and competition of technical fields as well as their commercial value, therefore the focus of analysis contents of bibliometrics and patentometrics are different. Basic laws and software in bibliometrics can also be applied to patentometrics but should be adjusted to account for the characteristics of patents. The paper-patent joint analysis can be achieved by studying the connections of papers and patents in research area, institutes or authors, citations and key words.
Peer Review Status:Awaiting Review
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] The formulation and implementation of big data policies is an important means for the country to promote the development of the big data industry. Therefore, research on big data policies has received widespread attention from the society.[Method/process] From the perspective of text similarity, the article compares the Big Data Development Action Plan issued by the State Council and the texts of big data policies released in 22 regions.[Result/conclusion] Data shows:the policies formulated by Guangdong Province and Fujian Province are the most complete and comprehensive;open data sharing and security guarantees the highest overall attention in the formulation of big data policies in various regions, showing similarity;regional characteristics are more prominent, showing differences. With the successive release of artificial intelligence policies in various regions, future research on big data policies under the vision of artificial intelligence will become a new direction.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： The foreign academician system originating from Europe derives from the internationalization of the academician system and is also an important part of internationalization. Drawing on international practices, the foreign academician system of Chinese Academy of Sciences (CAS) was established in 1994 after a long and tortuous design process. With the development of globalization, foreign academicians have increasingly become an influential force in international cooperation and exchanges. To ensure the better functioning of foreign academicians, major western countries have formed effective mechanisms in their construction process. And our system has fully absorbed international experience and is also deeply rooted in the process of localization. The continuous improvement of comprehensive strength and the influence of the long history have formed our own characteristics. This work comparatively study the development and working mechanism of foreign academician systems. On this basis, some measures are put forward to further optimize the CAS's foreign academician system.
Subjects: Psychology >> Social Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Syntax refers to the phenomenon that an organism is able to form a new high-level language unit from several relatively low-level language units based on certain rules, it is an important characteristic of human communication system that distinguishes humans from other animals. According to the saltation view, syntax is the ability developed by human ancestors alone after the differentiation with other primates in evolution. In the history of human evolution, there is no pre- syntax stage. The gradual view holds that syntax has an evolutionary continuity in the primate lineage. Although the brain systems responsible for complex syntax processing are unique to humans, the sequential learning that underlies syntax processing can be traced back to older primates, but it has been further enhanced in humans. The ability of sequence learning to extract, summarize and generalize the abstract structural relations among multiple stimuli is an important cognitive basis for human to implement syntax processing. Numerous studies have shown that in artificial grammar tasks, many species of primate can summarize and master the sequence of stimuli. There has been a gradual evolution in sequence processing between other primates and humans. Comparative studies from neurobiology suggest that the neural mechanisms that support serial order processing and simple grammar stem from the more ancient brain regions that humans share with other primates. It is these brain regions that allow other primates to understand and master ordering in artificial grammatical tasks. The neural mechanisms that support hierarchical structure processing and complex grammar come from areas of the brain that are unique to humans and emerged much later in evolution. So though complex grammar is not present in other primate communication systems, the sequence learning on which human syntactic processing depend stems from a cognitive mechanism that has existed in the evolutionary history of primates. The gradual view poses a challenge to the explanation of the origins of syntax: if simple sequential processing is common to primates, why should it be that only humans have evolved complex grammatical mechanisms based on it? Several hypotheses have tried to answer this question. The Lexical Limitation Hypothesis suggests that the emergence of unique syntax in humans stems from the growth of vocabulary. This theory emphasizes the pressure exerted on the evolution of grammatical mechanisms by ‘information content’, that is, the expansion of expressed content leads to structured language. The Event Perception Hypothesis holds that syntax originated from the way organisms mentally perceive and represent natural events. According to this theory, syntax is the product of the co-evolution of human event coding system and expression system. The Self-Domestication Hypothesis holds that syntax evolved from self-domestication. Offensive language can belittle your competitors and show your strengths at the same time. In the process of human self-domestication, verbal aggression gradually replaced physical aggression and became an alternative means of social competition. This shift, in turn, imposes feedback and evolutionary demands on language itself, leading to the emergence of syntax and complex language forms. These theories discuss the evolutionary origin of grammar from different perspectives, but all of them have insufficient explanatory power. In the field of language evolution research, no theory has been able to fully answer the question of the origin of human syntax. In fact, it is not necessarily a single factor that has dominated syntax evolution. For example, self-domestication reduces interpersonal conflict and increases the frequency of mutual learning, communication and cooperation, thus creating a favorable environment for more knowledge sharing and information dissemination. Complex language allows community members to communicate with each other on interpersonal relationships, thus forming positive feedback on intimate relationships and cooperative alliances. Diversified social interaction makes human beings have a unique tendency of event perception. It was the interaction of different factors at different times that led to the eventual development of mature syntax mechanism in humans. Future research should clarify whether the neural mechanisms found in artificial grammar tasks are common processors for hierarchical processing in all fields, and further explore the relationship between syntactic processing and semantic processing.
Subjects: Psychology >> Other Disciplines of Psychology submitted time 2021-01-24
Abstract： Syntax is an important characteristic of human communication system that distinguishes humans from other animals. Comparative behavioral studies have shown that other primates besides humans can understand serial order rules; Comparative neurobiological studies have shown that the neural mechanisms that support order processing come from brain regions shared by humans and other primates. Therefore sequence learning ability on which syntax depends have evolutionary continuity between humans and other primates. Lexical constraint hypothesis, event perception hypothesis and self-domestication hypothesis explain the evolutionary origin of human syntax from different perspectives. Future research should clarify whether the neural mechanisms found in artificial grammar tasks are common processors for hierarchical processing in all fields, and further explore the relationship between syntactic processing and semantic processing.
Peer Review Status:Awaiting Review
Subjects: Other Disciplines >> Synthetic discipline submitted time 2017-06-29 Cooperative journals: 《中国科学院院刊》
Abstract：在系统梳理科技创新决策与咨询制度概念及研究进展的基础上，以主要发达国家科技创新决策与咨询制度的基本现状和基础架构为主线，分析可资借鉴的经验。结合我国建立科技创新决策与咨询系统的需求，提出建立、完善国家科技创新决策与咨询制度的政策建议：建立国家宏观科技创新决策领导机构，减少政府创新管理职能重复；设立国家科技创新决策咨询机构，建立常态化联系沟通机制；加快推动决策咨询和智库体系建设法治化，建立多渠道、不同运行模式的科技创新顾问制度体系，不断探索并创新咨询模式和运行方式；加强科技创新决策与咨询能力建设，提高决策与咨询质量。
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