The Structure of 30 nm Chromatin Fiber and Its Regulation

分类： 生物学 >> 生物物理学 >> 生物物理、生物化学与分子生物学 提交时间： 2016-05-11

Liang Dan Chen Ping Li Guo-Hong

摘要： In eukaryotic cells, genomic DNA is hierarchically packed into chromatin by histones in the nucleus. Despite of over 30 years' study, the fundamental structure of 30 nm chromatin fiber remains controversial. In this review, we focus on recent progress in revealing the structure of 30 nm chromatin fiber, and emphasize on the most recent left-handed double helix structure of 30 nm chromatin fiber. In addition, we discuss the epigenetic regulation of the 30 nm chromatin structure. Finally, we discuss the possible challenge in elucidating the structure of 30 nm chromatin fiber and its regulation.

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