Adipose Tissue and the Pathogenesis of Obesity-related Hypertension postprint

Abstract: The global prevalence of hypertension related to obesity is sharply increasing，drawing significant attention in the medical field. Obesity complicates the management of high blood pressure and aggravates cardiovascular damage and disease burden. The abnormal expansion and remodeling of adipose tissue，which is central to obesity，are closely linked to mechanisms behind hypertension，including the renin-angiotensin-aldosterone system，adipokine imbalances，inflammation，sympathetic nervous system activation，and insulin resistance. This review synthesizes current knowledge on adipose tissue，highlighting its classification，distribution，pathological mechanisms，and connections to obesity-related hypertension. It also reviews current evidence and research directions，offering new perspectives for research and potential therapeutic targets.