Mechanisms and Therapeutic Research of Mitochondria in Ferroptosis Following Cerebral Hemorrhage postprint

Abstract: Intracerebral hemorrhage（ICH）is a type of stroke with high mortality and disability rates. Ferroptosis plays a significant role in the secondary injury following ICH. Mitochondria，as the center of cellular metabolism and energy production，have an important role in ferroptosis. Exploring the role of mitochondria in ferroptosis is of great significance for the treatment of secondary injuries after ICH. This article will discuss the role of mitochondria in ferroptosis from various aspects，including mitochondrial reactive oxygen species（ROS）and mitochondrial permeability transition pore（mPTP），mitochondrial tricarboxylic acid（TCA）cycle，mitochondrial autophagy，mitochondrial DNA（mtDNA），and mitochondrial dihydroorotate dehydrogenase（DHODH），in the context of ferroptosis following ICH. It will also review the latest research on targeting mitochondria for the treatment of ferroptosis，providing new insights for the intervention of secondary injuries after ICH.