The Prevalence of Hyperuricemia among Children and Adolescents in China：a Meta-analysis postprint

Abstract: Background  The estimation of the prevalence of hyperuricemia in children and adolescents is extremely important for understanding the disease burden of hyperuricemia and the rational allocation of corresponding health resources. Objective  To systematically analyze the prevalence of hyperuricemia in children and adolescents in China. Methods  The prevalence of hyperuricemia in Chinese children and adolescents was searched by CNKI，Wanfang Data，VIP，PubMed，Embase，Web of Science，and Scopus databases published before September 2024. Meta-analysis was performed using Stata 17.0 software，and subgroup analyses were performed on the prevalence of hyperuricemia by survey time，survey area，gender，age，body mass index，data source，and sample size. Results  A total of 39 papers were included，with a total sample size of 156，006 cases，and the prevalence of hyperuricemia in children and adolescents in China was 20.93%（95%CI=17.77%-24.10%）. The results of subgroup analysis showed that the prevalence of hyperuricemia was higher in children and adolescents who were boys（prevalence=24.42%，95%CI=19.87%-28.97%），12-19 years old（prevalence=32.20%，95%CI=22.35%-42.06%），overweight/obesity（prevalence=38.78%，95%CI=27.79%-49.78%），South（prevalence=31.59%，95%CI=25.54%-37.64%）and surveyed from 2017-2023（prevalence=24.42%，95%CI=19.87%-28.97%）（P<0.05）. The results of the analysis of different age groups by gender showed that the prevalence of hyperuricemia was significantly higher among boys in the age group of 12-19 years（prevalence=46.79%，95%CI=37.51%-56.07%）（P<0.05）. Conclusion  The overall prevalence of hyperuricemia in children and adolescents in China is high，and the rate of increase in prevalence accelerates significantly after puberty，which should be emphasized.