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Neuroendocrine carcinoma of the cervix: The value of postoperative radiation in early-stage disease

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Краткое изложение: Objective: The current treatment for early-stage neuroendocrine carcinoma of the cervix (NECC) mainly relies on radical hysterectomy and chemotherapy. The routine use of postoperative radiation is still in controversial. We want to evaluate the value of postoperative radiation in early-stage NECC. 
Methods: A retrospective cohort study. Early-stage NECC patients from 2006 to 2022 in Peking Union Medical College Hospital were included. Depending on whether the patients received radiation therapy after surgery, they were divided into Postoperative non-radiation group (Group A) and Postoperative radiation group (Group B). We use Kaplan-Meier method to analyze the progression-free survival (PFS), overall survival (OS), recurrence and OS rate. 
Results: Sixty-six cases were included, 32 (48.5%) in Group A and 34 (51.5%) in Group B. After 35 (range 12-116) months follow-up, 26 (39.4%) experienced recurrence. Compared with Group A, Group B had lower pelvic recurrence rate (12.5% vs 2.9%, p = 0.142), slightly higher distant recurrence rate (28.1% vs 44.1%, p = 0.177), and similar mortality rate (29.4% vs 31.3%, p = 0.871). Cervical stromal invasion ≥1/2 was more common in Group B (28.0% vs 63.0%, p = 0.012). Postoperative radiation in patients with cervical stromal invasion ≥1/2 showed an extended trend in PFS (33.9 months vs 47.9 months) and OS (40.7 months vs 70.0 months) but without statistical difference (p = 0.963, p = 0.636). Lymph-vascular space invasion (LVSI) is a high-risk factor for tumor recurrence (HR 9.13, p = 0.005), but radiation after surgery did not improve the PFS (51.5 months vs 48.8 months, p = 0.942) and OS (53.9 months vs 60.6 months, p = 0.715) in patients with LVSI.
Limitations: The limitations of this study are the retrospective nature and relative small sample size.
Conclusions: Postoperative radiation seems to prolong PFS and OS in patients with cervical stromal invasion ≥1/2. LVSI was a high-risk factor for tumor recurrence, but radiation after surgery in patients with LVSI seems have no survival benefits. 
  • из 宋晓晨
  • Категоризация: 医学、药学 >> 临床医学
  • инструкции: 研究主要结论及亮点 Routine postoperative radiation in neuroendocrine cervical cancer patients may reduce pelvic recurrence but not overall recurrence or death. In neuroendocrine cervical cancer patients with cervical stromal invasion 1/2, postoperative radiation had trend of prolonging PFS and OS. In neuroendocrine cervical cancer patients with lymph-vascular space invasion, postoperative radiation seems had no survival benefit.
  • Состояние представления: 未投稿
  • Цитировать: ChinaXiv:202309.00238 (или эта версия ChinaXiv:202309.00238V1)
    DOI:10.12074/202309.00238V1
    CSTR:32003.36.ChinaXiv.202309.00238.V1
  • 科创链TXID: 44c04a8d-7404-4be9-8f85-2ef9c41d0d69
  • Рекомендуемое цитирование: 宋晓晨,张卉,钟森,谭先杰,马水清,金滢,潘凌亚,吴鸣,曹冬焱,杨佳欣,向阳.Neuroendocrine carcinoma of the cervix: The value of postoperative radiation in early-stage disease.null.[DOI:10.12074/202309.00238V1] (Нажмите здесь, чтобы скопировать)

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[V3] 2025-02-17 09:41:46 ChinaXiv:202309.00238v3 Посмотреть эту версию Скачать полный текст
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[V1] 2023-09-28 19:08:12 ChinaXiv:202309.00238V1 Скачать полный текст
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