分类： 物理学 >> 核物理学 提交时间： 2024-11-28
Xu, Dr. Zhao
Liu, Dr. Qi
Li, Prof. Wen-Yi
Feng, Ms. Guangyan
Lu, Mr. Yu
Ding, Ms. Ziyi
Li, Dr. Tao-Sheng
摘要： This study investigates the hyper-radiosensitivity (HRS) and induced radioresistance (IRR) effects in cells exposed to low-dose radiation, focusing on identifying critical dose thresholds and exploring underlying molecular mechanisms. By analyzing cell survival data using a normal distribution-based mathematical model, we determined two key dose thresholds: D0 , where repair mechanisms are activated, and D1 , where repair and damage rates equilibrate. Our findings reveal that ATM (ataxia-telangiectasia mutated) and p53 proteins play central roles in modulating these thresholds, with wild-type p53 cells demonstrating faster repair initiation and mutant p53 cells exhibiting broader response curves. The results show that cellular outcomes depend on both genetic background and radiation dose, with potential implications for optimizing radiotherapy protocols and developing radioprotective strategies. This work provides a quantitative framework for understanding HRS and IRR phenomena and contributes to advancing personalized approaches in radiation medicine.
分类： 物理学 >> 核物理学 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： The reliability of radiotherapy was evaluated and effective approaches were obtained in order to improve radiotherapy quality by using the Probabilistic Safety Assessment (PSA) method. This study investigated the feasibility of the PSA method being applied to radiotherapy through Image-guided Radiotherapy (IGRT) and chest tumor irradiation. A fault tree has been constructed after analyzing causal relationship of the events. After calculating RiskA, a total inaccuracy radiotherapy probability and the importance of all base events were obtained. The probability of inaccurate radiotherapy was 2.87%. Under the condition that the target delineation was perfectly right, the accuracy of radiotherapy significantly improved. With the calculation without Cone-beam Computed Tomography (CBCT) being corrected before irradiation, the accuracy significantly decreased. The most important events were connected with the human factor. Improving human technical level could enhance radiotherapy quality control efficiently.
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