Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2025-07-17 Cooperative journals: 《中国全科医学》
Abstract： The global prevalence of hypertension related to obesity is sharply increasing，drawing significant attention in the medical field. Obesity complicates the management of high blood pressure and aggravates cardiovascular damage and disease burden. The abnormal expansion and remodeling of adipose tissue，which is central to obesity，are closely linked to mechanisms behind hypertension，including the renin-angiotensin-aldosterone system，adipokine imbalances，inflammation，sympathetic nervous system activation，and insulin resistance. This review synthesizes current knowledge on adipose tissue，highlighting its classification，distribution，pathological mechanisms，and connections to obesity-related hypertension. It also reviews current evidence and research directions，offering new perspectives for research and potential therapeutic targets.
Subjects: Nursing >> Nursing submitted time 2023-01-17
Abstract：
Objective To investigate the value of quality control circle (QCC)activities in reducing the incidence of adverse factors for rapid recovery after surgical treatment for laryngeal cancer. Methods A convenient sample of 35 patients with surgical treatment for laryngeal cancer were selected as the control group, another 28 patients were recruited as the observation group. The quality control circle(QCC) activity group was set up by the medical and nursing integration. Based on the clinical practice, the adverse factors affecting the rapid recovery of laryngeal cancer patients were found, analyzed and improved through the QCC activities, and the effect analysis was carried out. Results Quality evaluation had been taken 225 times in the control group and 224 times in the observation group , respectively. The incidence of adverse factors affecting the rapid recovery of patients with laryngeal cancer decreased from 46.67% （105/225）to 11.61%（26/224）, with a target achievement ratio of 126.56%. Shorter length of hospital stay and lower cost of hospitalization were found in the observation group than those in the control group （P＜0.05）. Conclusion The QCC activity an effective management tool for reducing the incidence of adverse factors in rapid recovery of laryngeal cancer patients, promoting medical and nursing cooperation, optimizing clinical pathways, improving the quality of medical care, shortening the length of hospitalization and reducing medical costs.
Peer Review Status:
Awaiting Review
Subjects: Agriculture, Forestry,Livestock & Aquatic Products Science >> Plant Protection submitted time 2018-06-22 Cooperative journals: 《广西植物》
Abstract：水稻异源三聚体G 蛋白系统中的非典型γ亚基GS3，是一个控制籽粒大小的主效数量效应基因座，在调节籽粒大小中发挥负调节子的功能，但是其直接相互作用的蛋白研究甚少，相关的机制尚未阐明。BioID (proximity-dependent biotin identification) 为邻近蛋白标记技术，其工作原理是：生物素连接酶能使其周围的蛋白带上生物素，同时生物素又能和链霉亲和素紧密结合，所以能够利用链霉亲和素偶联的磁珠富集目标蛋白。该技术具有灵敏、高效和周期短等特点，为筛选互作蛋白提供了新的方法。本文以水稻原生质体为材料，采用BioID 技术对GS3 在水稻中的互作蛋白进行了筛选。Western-blot 结果表明，融合蛋白BirAG-GS3在原生质体中成功表达并生物素化GS3 邻近蛋白。使用链霉亲和素磁珠富集生物素化后的蛋白，并进行蛋白质谱测序，获得了与GS3 邻近的可能存在直接或间接互作的蛋白。将获得的蛋白进行功能富集与注释，并构建蛋白-蛋白互作网络。对部分蛋白进行了BiFC 验证，发现GS3 可能与ICL、PPDK、RPN7 和RH15 发生相互作用，涉及能量代谢的调节、种子淀粉物质的储存、泛素-蛋白酶体系统，以及凋亡途径等生物过程。上述结果为解析GS3 的蛋白调控网络奠定了基础。
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