Subjects: Library Science，Information Science >> Library Science submitted time 2023-08-27 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] There is an impact on the collection development and services of research libraries under the environment of open science. Analyzing the status quo of transition of the representative research library, the U.S. National Library of Medicine under the environment of open science, will provide a reference for the transformation of domestic research library under the environment of open science. [Method/process] On the basis of analyzing the elements of open science, this article summarizes the evolution of the National Library of Medicine at the strategic level in response to the development needs of the open science from three perspectives: library development strategy, library collection development and library services. It focuses on the analysis of its collection development practices (including open resource construction, data center construction, semantic organization of resources, development of software tools, etc.) and service practices (including open sharing services of scientific information, public information services, data management services, open education services, new media and mobile services, etc.).[Result/conclusion] The National Library of Medicine implemented the requirements of the development of open science well from five aspects: policy guidance, resource basis, platform support, service type and service channel. The research library should gradually shift from information resource center to data center and promote the open scientific development from the perspectives of strategic decision-making, open access platform construction, data center construction and software tools development.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-07-19 Cooperative journals: 《中国全科医学》
Abstract： Background Early neurological deterioration（END）is common after acute ischemic stroke，which contributes to increased functional impairment and mortality in patients. Triglyceride glucose index（TyG index）is an independent predictor of the severity of neurological deficits in patients with acute ischemic stroke and is also associated with early recurrent ischemic lesions，however，its correlation with the incidence of END in recent single subcortical infarction（SSI）hasbeen rarely reported and the correlation remains unclear. Objective To investigate the correlation between TyG index and the incidence of END in patients with recent SSI. Methods A total of 197 patients diagnosed with SSI and admitted within 72 h after symptom onset in the department of neurology，the Third Hospital of Hebei Medical University from 2020 to 2021 were included in the study and divided into the END group（n=45）and non-END group（n=152）based on whether END was developed. The clinical data of the patients were collected and multivariate Logistic regression analysis was used to investigate the correlation between TyG index and the incidence of END in patients with recent SSI. Receiver operating characteristic（ROC）curves were plotted to assess the predictive value of TyG index for END in patients with recent SSI. Results The proportion of patients with diabetes，FBG，TG and TyG index were higher in the END group than the non-END group（P<0.05）. Multivariate Logistic regression showed that elevated TyG index was a risk factor for END in patients with recent SSI〔OR=1.726，95%CI（1.008，2.956），P=0.047〕. On different lesion infarct sites，elevated TyG index was a risk factor for END in SSI patients with basal ganglia as the infarction area〔OR=3.164，95%CI（1.290，7.760），P=0.012〕. Elevated TyG index was not associated with the occurrence of END in SSI patients with centrum semiovale as the infarction area（P>0.05）. The ROC area under the curve（AUC）of TyG index for predicting END in patients with recent SSI was 0.66〔95%CI（0.57，0.75），P=0.001〕，with an optimal cut-off value of 8.61，sensitivity of 0.689 and specificity of 0.638. Patients were divided into those with TyG index ≥ 8.61 and those with TyG index <8.61 according to the optimal cut-off value of TyG index. Compared with those with TyG index<8.61，patients with TyG index ≥ 8.61 had higher proportion of hyperlipidemia and diabetes，as well as higher levels of FBG，TC，TG，LDL and increased proportion of END，with lower age and HDL（P<0.05）. Conclusion TyG index is correlated with END in SSI patients，and increased TyG index is an independent risk factor for END in SSI patients，and the correlation varies depending on the location of the lesion.
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