Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2025-07-18 Cooperative journals: 《中国全科医学》
Abstract： Background As one of the serious chronic complications of diabetes，diabetic foot is characterized by high rate of disability and high burden of diseases. which require multi-disciplinary collaboration and long-term standardized management in the prevention and treatment of diseases. At present，there are many difficuties during the management of diabetic foot in all community-level medical and health care institutions，such as insufficient specialized resources and lack of continuous care .Objective Through the analysis of a successful management path in diagnoses and treatments process of a case of type 2 diabetes patient complicated with diabetic foot，to investigate the feasibility of promoting the co-care management model based on the“Specialist-General Practitioner”family medicine team contractual services in the management of diabetic complications in community health service center. Methods Through combing and analyzing the whole treatment and management pathway of a diabetes foot patient under the new model of "Specialist-General Practitioner"family medicine team contractual services. we searched for relevant literature from 2004 to 2024 in the full-text journal of CNKI database，Wan-fang database，Vip database and PubMed database with the key words of “Diabetic foot，Community”in Chinese and“Diabetic foot and Management，Diabetic foot and Administration，Community diabetic foot”in English. The results showed that the new model for co-care management in diabetic foot had more obvious advantage and widespread concern than the existing community management models and contents. Results Under the new model of "Specialist-General Practitioner"family medicine team contractual services，the patient's gangrenous toes linked to his diabetes were preserved and the foot infection associated with diabetes was cured. Meanwhile，the patient's blood sugar，blood lipids，and blood pressure gradually reached the standard of good control.According to the document retrieval results，it is found that most of the management models for community diabetes foot at home and abroad are still in the primary stage，including community-based management model，hospital-community linkage management model，hospital-community-family management model，Internet plus hospital-community-family intelligent nursing model，self-management model，multidisciplinary teams management，telemedicine model by using computer software，smartphones，apps running on tablets，network camera and other devices，artificial intelligence prediction model for diabetes foot ulcers and multi-disciplinary integration of diabetes foot management team. Conclusion The co-care model based on "Specialist-General Practitioner"family medicine team contractual services got remarkable effect on the management of diabetes foot in the community. Compared to the similar models in China and abroad，this model has a simple team structure，clear division of labor among members，emphasis on individualization of services，and work more efficiently，，which is worth spreading and applying in the community health service center.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-02-05 Cooperative journals: 《中国全科医学》
Abstract： Background Gastrointestinal symptoms in gastric cancer patients treated with postoperative chemotherapy are diverse and interconnected，with a lack of effective intervention targets. In recent years，network analysis has emerged as a prominent approach to identify intervention targets. Objective To construct a network of gastrointestinal symptoms in gastric cancer patients treated with postoperative chemotherapy，identify core symptoms and analyze the factors influencing core symptoms，so as to provide a reference for precise symptom management. Methods Convenience sampling method was used to select postoperative chemotherapy patients with gastric cancer in the medical oncology and surgical oncology department of four tertiary-level Chinese medicine hospitals（Jiangsu Provincial Hospital of Traditional Chinese Medicine，Suzhou Hospital of Traditional Chinese Medicine，Wuxi Hospital of Traditional Chinese Medicine，and Xuzhou Hospital of Traditional Chinese Medicine） in South，Central，and North Jiangsu Province，from March to December 2022，as the study subjects. The MD Anderson Symptom Inventory Gastrointestinal Cancer（MDASI-GI）was used for evaluating gastrointestinal symptoms and their severity among patients receiving postoperative chemotherapy for gastric cancer，as well as assessing the classification of traditional Chinese medicine constitution among patients. The network of gastrointestinal symptoms was constructed using an R package to identify the centrality indexes. The univariate analysis and multiple linear regression analysis were conducted to investigate factors influencing core gastrointestinal symptoms in patients undergoing postoperative chemotherapy for gastric cancer. Results A total of 362 electronic questionnaires were collected，355 were valid，with a valid recovery rate of 98.1%. The highest incidence of gastrointestinal symptoms in patients with postoperative chemotherapy for gastric cancer was lack of appetite（83.1%），taste alteration（81.7%）and nausea（71.0%），and the top three in terms of severity were lack of appetite（2.77 points），taste alteration（2.50 points）and nausea（2.27 points）. Network analysis showed that taste alteration had the highest intensity（rS=1.27）and the highest tight centrality（rC=1.50）；vomiting had the highest betweenness centrality（rB=1.76）. The results of univariate analysis showed statistically significant differences in the severity scores of taste alteration symptoms among postoperative chemotherapy patients with gastric cancer of different genders，smoking histories and traditional Chinese medicine constitutions（P<0.05）. The results of multiple linear regression analysis showed that gender，smoking history and phlegm-damp substance were the factors influencing the severity of taste alteration symptoms in patients with gastric cancer after chemotherapy（P<0.05）. Conclusion Taste alteration is the core symptom of gastrointestinal symptoms in gastric cancer patients undergoing postoperative chemotherapy. Gender，smoking history，and phlegm-damp substance are influential factors contributing to taste alteration. Nursing staff can develop intervention strategies based on these core symptoms and their influencing factors to enhance the efficacy of managing gastrointestinal symptoms during chemotherapy in gastric cancer patients.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Previous studies on self-other welfare tradeoff focus more on the gain situations than the loss situations. Numerous studies have explored the influence of social distance on the tradeoff but ignored the complex interactions among gain and loss situations, others’ reference points, and psychological distance. This study investigated the influences of others’ reference points and psychological distance on self-other welfare tradeoff in gain and loss situations by using welfare tradeoff rate (WTR) as an index of altruistic degree in self-other welfare tradeoff. In Experiment 1, the effect of WTR on the gain and loss situations and its mechanism were explored. In Experiment 2, others’ reference points were added as another factor to examine their influence on WTR and interaction with the gain and loss situations. In Experiment 3, the psychological distance variable was further introduced to investigate its influence on WTR and interaction with the gain and loss situations and others’ reference points. Results of Experiment 1 showed no significant difference in WTR between gain and loss situations. In Experiment 2, WTR in the gain situation was found to be significantly higher than that in the loss situation, and WTR was reduced when others approached the bottom line, goal, and status quo. Further analyses showed that the WTR under the gain situation was significantly higher than that under the loss situation when others approached the bottom line. Meanwhile, no significant difference was observed in the WTR under the gain and loss situations when others approached the status quo and goal. In Experiment 3, the WTR of close psychological distance was found to be higher than that of far psychological distance, and the main effect of gain and loss situations disappeared. Psychological distance had complex interaction effects with gain and loss situations and others’ reference points. These findings contribute to a deep understanding of the asymmetric effects of gain and loss situations, tri-reference-point theory, and related findings from studies on social discounting and self-other decision- making differences. They also have certain practical implications for individuals, organizations, and countries in understanding and dealing with the relationships between ones’ selves and others.
Subjects: Psychology >> Other Disciplines of Psychology submitted time 2019-09-22
Abstract： Death awareness refers to thinking about and the recognition of the inevitability of personal death. As a critical component of the human-unique ability of autonoetic consciousness, death awareness can be viewed as a cognitive adaptation for time management. We hypothesize that activating death awareness may affect intertemporal choice, in which people make tradeoffs between rewards across different time points. Such effects of death awareness on intertemporal choice may be mediated by time perception, a subjective assessment of the speed of time passage. In this research, we investigate the impact of death awareness on time perception and intertemporal choice, and the relationships among them. Study 1 examined the relationship between death awareness and time estimation. Eighty-three college students were randomly assigned to either a death awareness activation group where mortality was made salient to the participants or a control group where the participants imagined their toothache experience. After a word-search distraction task, the participants in both groups completed a time-passage (400ms, 800ms, 1200ms, 1600ms) estimation task. The results showed that the participants in the group of death awareness activation gave significantly shorter estimates than the participants in the control group. Study 2 (n = 123) extended the measure of time perception to a more extended period and also measured the delay discounting rate of the participants from their intertemporal choices between a smaller-and-sooner reward and a larger-and-later reward. The participants were randomly assigned to either a death awareness activation group or a toothache awareness activation group. The participants then indicated how long ten years was to them by marking on a line with the statement “10 years is very short” on the left end side of the line and the statement “10 years is very long” on the right end side. The participants in the death-awareness activation group marked the line closer to the left end (“life is short”) than those in the control group. As predicted, the participants in the death-awareness activation group had a lower delay discounting rate and were more future-oriented in making intertemporal choices. Moreover, bootstrapping analysis revealed a partial mediation effect of time-passage estimation between death awareness and delay discounting. In conclusion, death awareness serves adaptive functions in time management. Activating death awareness makes people feel that time passes more quickly and promotes future-oriented decisions.
Subjects: Biology >> Bioengineering submitted time 2017-07-24 Cooperative journals: 《中国生物工程杂志》
Abstract： Phenol is a typical environmental pollutant. Biodegradation of phenol Phenol is a typical environmental pollutant. Chlorella sp. is potential strain for wastewater treatment because of its fast growth and strong resistance. Chlorella sp. could degrade phenol in industrial wastewater but oxidative stress induced by high concentration of phenol could cause oxidative damage in algal cells. Adaptive evolution was performed to improve the tolerance to phenol of Chlorella sp (L5). in previous study. The response mechanism of Chlorella sp. to oxidative stress induced by high concentration phenol was explored by de novo comparative transcriptomic analysis on genome scale. It was shown that the evolved strain could tolerate and degrade phenol was related to metabolic regulations in multiple pathways. The results of de novo comparative transcriptomic analysis showed that the genes related to signal transduction, ABC transporter and heat shock protein were significantly up-regulated at 500 mg/L phenol concentration compared to those in the original (L3) cells. Those genes in nitrogen metabolism and tricarboxylic acid cycle (TCA) were also upregulated. The evolved strain (L5) could reduce oxidation pressure induced by high concentration of phenol through the metabolic regulations in these metabolic pathways.
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